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Simvastatin

Cat. No. 1965 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： HMG-CoA reductase inhibitor
化学名： (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Simvastatin

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

化合物库 for Simvastatin

Simvastatin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Simvastatin

分子量 418.57
公式 C25H38O5
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 79902-63-9
PubChem ID 54454
InChI Key RYMZZMVNJRMUDD-HGQWONQESA-N
Smiles [H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C[C@H](C)C[C@@H]1OC(C(C)(C)CC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Simvastatin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.93 50
ethanol 31.39 75

制备储备液 for Simvastatin

以下数据基于产品分子量 418.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 3.19 mL 15.93 mL 31.85 mL
3.75 mM 0.64 mL 3.19 mL 6.37 mL
7.5 mM 0.32 mL 1.59 mL 3.19 mL
37.5 mM 0.06 mL 0.32 mL 0.64 mL

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产品说明书 for Simvastatin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Simvastatin

参考文献是支持产品生物活性的出版物。

Garrett et al (2001) STAT and bone formation. Curr.Pharm.Des. 7 715 PMID: 11405194

Kaushal et al (2003) Potential anticancer effects of STAT: fact or fiction? Endothelium 10 49 PMID: 12699077

White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111 PMID: 11563401

Reinoso et al (2002) Preclinical pharmacokinetics of STAT. Methods Find.Exp.Clin.Pharmacol. 24 593 PMID: 12616706

Luttman et al (2021) ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. Cell Rep. 37 109880 PMID: 34706244

Dehnavi et al (2021) Targeting AMPK by statins: A potential therapeutic approach. Drugs 81 923 PMID: 33939118

If you know of a relevant reference for Simvastatin, please let us know.

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关键词: Simvastatin, Simvastatin supplier, HMG-CoA, reductase, inhibitors, inhibits, reductases, ferroptosis, hyperlipidemia, hypolipemic, statins, AMPK, autophagy, Reductase, Ferroptosis, Autophagy, 1965, Tocris Bioscience

4 篇 Simvastatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Simvastatin 的部分引用包括：

Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Br J Pharmacol 8 e66404 PMID: 23799098

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Pharmacol Res Perspect 2 1176 PMID: 22202492

Seto et al (2007) Modulation by SimV. of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Oncotarget 151 987 PMID: 17558433

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Simvastatin 的评论

平均评分: 5 (Based on 1 Review.)

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Role of mevalonate pathway inhibitor for protection of joint degeneration.
By Anonymous on 03/22/2018
分析类型： In Vitro
种属： Other
细胞系/组织： cartilage

I used this drug to test the role of mevalonate pathway in joint integrity

It works well and the price is nice.

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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