SK 216

Cat. No. 6187 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Plasminogen activator inhibitor-1 (PAI-1) inhibitor

化学名： 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SK 216

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

技术数据 for SK 216

分子量	533.52
公式	C₂₉H₂₉NO₆Na₂
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	654080-03-2
PubChem ID	131954585
InChI Key	YYTGMMYYLGKWIK-UHFFFAOYSA-L
Smiles	CC(C)(C)C1=CC=C(OC(C2=CC(C=CC(OCCCCCC(C(O[Na])=O)C(O[Na])=O)=C3)=C3C=C2)=N4)C4=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SK 216

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	2.67	5 温和加热

制备储备液 for SK 216

以下数据基于产品分子量 533.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.05 mM	37.49 mL	187.43 mL	374.87 mL
0.25 mM	7.5 mL	37.49 mL	74.97 mL
0.5 mM	3.75 mL	18.74 mL	37.49 mL
2.5 mM	0.75 mL	3.75 mL	7.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for SK 216

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SK 216

参考文献是支持产品生物活性的出版物。

Omori et al (2016) Inhibition of plasminogen activator inhibitor-1 attenuates transforming growth factor-β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to myofibroblasts. PLoS One. 11 e0148969 PMID: 26859294

Takayama et al (2016) Inhibition of PAI-1 limits tumor angiogenesis regardless of angiogenic stimuli in malignant pleural mesothelioma. Cancer Res. 76 3285 PMID: 27197170

Masuda et al (2013) SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol.Cancer Ther. 12 2378 PMID: 23990114

If you know of a relevant reference for SK 216, please let us know.

按标靶查看相关产品

关键词: SK 216, SK 216 supplier, SK216, plasminogen, activator, inhibitor-1, inhibitors, inhibits, PAI-1, angiogenesis, antiangiogenesis, Mesenchymal, Stem, Cells, Antiangiogenics, Plasminogen, Activator, Inhibitor, 1, 6187, Tocris Bioscience

篇 SK 216 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 SK 216 的引用文献。您是否知道使用了 Tocris SK 216 的优秀论文？请告知我们.

SK 216 的评论

目前没有该产品的评论。 Be the first to review SK 216 and earn rewards!

Have you used SK 216?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.