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Submit ReviewSKF 38393 hydrobromide
说明： Selective D1-like agonist
化学名： (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
纯度： ≥98% (HPLC)
生物活性 for SKF 38393 hydrobromide
SKF 38393 hydrobromide is a prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).
化合物库 for SKF 38393 hydrobromide
SKF 38393 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SKF 38393 hydrobromide
| 分子量 | 336.23 |
| 公式 | C16H17NO2.HBr |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 20012-10-6 |
| PubChem ID | 12928470 |
| InChI Key | INNWVRBZMBCEJI-UHFFFAOYSA-N |
| Smiles | Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SKF 38393 hydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 8.41 | 25 温和加热 | |
| DMSO | 33.62 | 100 |
制备储备液 for SKF 38393 hydrobromide
以下数据基于产品分子量 336.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for SKF 38393 hydrobromide
参考文献 for SKF 38393 hydrobromide
参考文献是支持产品生物活性的出版物。
Geter-Douglass et al (1997) Characterization of unconditioned behavioral effects of DA D3/D2 receptor agonists. J.Pharmacol.Exp.Ther. 283 7 PMID: 9336302
Habuchi et al (1997) DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 122 1669 PMID: 9422813
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
Sibley et al (1982) Interactions of novel DArgic ligands with D1 and D2 DA receptors. Life Sci. 31 637 PMID: 6127585
If you know of a relevant reference for SKF 38393 hydrobromide, please let us know.
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关键词: SKF 38393 hydrobromide, SKF 38393 hydrobromide supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF38393, hydrobromide, and, 0922, Tocris Bioscience
18 篇 SKF 38393 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SKF 38393 hydrobromide 的部分引用包括：
Grochowska et al (2017) Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep 18 962 PMID: 28420656
Moreno et al (2014) Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci 34 3545 PMID: 24599455
Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738
Murugan et al (2013) Diminished FoxP2 levels affect DArgic modulation of corticostriatal signaling important to song variability. Neuron 80 1464 PMID: 24268418
Zike (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. Proc Natl Acad Sci USA 114 5719 PMID: 28507136
Mi (2017) Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor. Plos One 12 e0168964 PMID: 28085967
Toro et al (2015) DA Modulates the Activity of Sensory Hair Cells. J Neurosci 35 16494 PMID: 26674873
Herwerth et al (2012) D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex 22 1786 PMID: 21955919
Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology 55 871 PMID: 18644393
Xing et al (2015) DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Eur J Neurosci 9 310 PMID: 26388722
Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Immunol 2 PMID: 26465004
Zhang et al (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci 59 4441 PMID: 30193315
Cilz et al (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels. Cereb Cortex 24 3195 PMID: 23843440
Burgess et al (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851
Hook et al (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Eneuro 35 507 PMID: 22304466
Prado et al (2012) Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Biol Chem 188 3062 PMID: 22379034
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Front Neurosci 283 26016 PMID: 18644790
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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