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Submit ReviewSLIGRL-NH2
说明： PAR2-activating peptide
纯度： ≥95% (HPLC)
生物活性 for SLIGRL-NH2
SLIGRL-NH2 is an agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.
Control Peptide also available.
技术数据 for SLIGRL-NH2
| 分子量 | 656.82 |
| 公式 | C29H56N10O7 |
| 序列 |
SLIGRL (Modifications: Leu-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 171436-38-7 |
| PubChem ID | 9831050 |
| InChI Key | SGPMJRPYYIJZPC-JYAZKYGWSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SLIGRL-NH2
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for SLIGRL-NH2
参考文献 for SLIGRL-NH2
参考文献是支持产品生物活性的出版物。
Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203 PMID: 8564891
Kawabata et al (2001) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br.J.Pharmacol. 133 1213 PMID: 11498505
Nystedt et al (1994) Molecular cloning of a potential proteinase activated receptor. Proc.Natl.Acad.Sci.U.S.A. 91 9208 PMID: 7937743
If you know of a relevant reference for SLIGRL-NH2, please let us know.
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关键词: SLIGRL-NH2, SLIGRL-NH2 supplier, PAR2-activating, peptide, Receptors, Protease-Activated, proteinase-activated, 1468, Tocris Bioscience
7 篇 SLIGRL-NH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SLIGRL-NH2 的部分引用包括：
Pandey et al (2017) A central role for R7bp in the regulation of itch sensation. Pain 158 931 PMID: 28134655
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
Antoniak et al (2013) Protease activated receptor-2 contributes to heart failure. EMBO J 8 e81733 PMID: 24312345
Sutherland et al (2019) Virus envelope tissue factor promotes infection in mice. J Thromb Haemost 17 482 PMID: 30659719
Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131
Vidwan et al (2010) Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30 2587 PMID: 20930172
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. PLoS One 30 582 PMID: 21139565
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SLIGRL-NH2 的评论
平均评分: 5 (Based on 1 Review.)
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Good and easy product to use for regular in-vitro stimulations.
By
Anonymous on 11/20/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Smooth Muscle Cells
Inv-vitro stimulation of PAR2 receptor in Smooth muscle cells