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SM 324405

Cat. No. 5445 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent TLR7 agonist
化学名： Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SM 324405

SM 324405 is a potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).

化合物库 for SM 324405

SM 324405 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SM 324405

分子量 385.42
公式 C19H23N5O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 677773-91-0
PubChem ID 23079483
InChI Key MXILFZWMVNDOIZ-UHFFFAOYSA-N
Smiles NC1=NC(OCCCC)=NC(N2CC3=CC=CC(CC(OC)=O)=C3)=C1NC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SM 324405

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.54 100

制备储备液 for SM 324405

以下数据基于产品分子量 385.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.97 mL 25.95 mL
5 mM 0.52 mL 2.59 mL 5.19 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for SM 324405

参考文献是支持产品生物活性的出版物。

Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID: 20232824

Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID: 22122192

If you know of a relevant reference for SM 324405, please let us know.

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关键词: SM 324405, SM 324405 supplier, SM324405, toll-like, receptors, TLR7, potent, agonists, agonism, Toll-like, Receptors, 5445, Tocris Bioscience

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Pathways for SM 324405

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.