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Submit ReviewSN 003
说明： Potent and selective CRF1 antagonist
化学名： N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
纯度： ≥98% (HPLC)
生物活性 for SN 003
Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.
技术数据 for SN 003
| 分子量 | 355.43 |
| 公式 | C19H25N5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 197801-88-0 |
| PubChem ID | 10291750 |
| InChI Key | FZMBHAQCHCEGNN-UHFFFAOYSA-N |
| Smiles | CCC(COC)N2C1=CC(C)=NC(NC3=CC=C(OC)C=C3C)=C1N=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SN 003
参考文献 for SN 003
参考文献是支持产品生物活性的出版物。
Kumar et al (2006) Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg.Med.Chem. 14 4029 PMID: 16529935
Sullivan et al (2007) PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density? Nucl.Med.Biol 34 353 PMID: 17499724
Zhang et al (2003) Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic J.Pharm.Exp.Ther. 305 57
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关键词: SN 003, SN 003 supplier, reversible, corticotropin, releasing, factor, receptors, 1, CRF1, CRF, antagonists, SN003, Receptors, 3294, Tocris Bioscience
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.