SN-6

Cat. No. 2184 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective Na⁺/Ca²⁺ exchange inhibitor (reverse mode)

化学名： 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester

纯度： ≥99% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SN-6

SN-6 is a selective Na⁺/Ca²⁺-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC₅₀ values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent ⁴⁵Ca²⁺ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC₅₀ = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC₅₀ > 30 μM). Preferentially blocks Ca²⁺ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC₅₀ = 0.63 μM).

化合物库 for SN-6

SN-6 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SN-6

分子量	402.16
公式	C₂₀H₂₂N₂O₅S
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	415697-08-4
PubChem ID	10222761
InChI Key	ZVYIJXLMBWCGHP-UHFFFAOYSA-N
Smiles	CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SN-6

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.22	100

制备储备液 for SN-6

以下数据基于产品分子量 402.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.43 mL	24.87 mL
5 mM	0.5 mL	2.49 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for SN-6

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SN-6

参考文献是支持产品生物活性的出版物。

Iwamoto et al (2004) The exchanger inhibitory peptide region-dependent inhibition of Na⁺/Ca²+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol.Pharmacol. 66 45 PMID: 15213295

Iwamoto (2004) Forefront of Na⁺/Ca²⁺ exchanger studies: molecular pharmacology of N⁺/Ca²⁺ exchange inhibitors. J.Pharmacol.Sci. 96 27 PMID: 15359084

If you know of a relevant reference for SN-6, please let us know.

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关键词: SN-6, SN-6 supplier, Selective, Na+/Ca2+, exchange, inhibitors, inhibits, reverse, mode, Sodium, Calcium, Exchanger, Ion, Transporters, Pumps, Ca2+, Signaling, Signalling, NCX1, 2184, Tocris Bioscience