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Submit ReviewSNAP 94847 hydrochloride
说明： Potent and selective MCH1 antagonist
化学名： N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SNAP 94847 hydrochloride
SNAP 94847 hydrochloride is a potent melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM, KD = 530 pM) that displays > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.
化合物库 for SNAP 94847 hydrochloride
SNAP 94847 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SNAP 94847 hydrochloride
| 分子量 | 515.03 |
| 公式 | C29H32F2N2O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1781934-47-1 |
| PubChem ID | 56972235 |
| InChI Key | DEDUDFNRQKUBRH-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(NC(C(C)C)=O)C=C1C(CC4)CCN4CC(C=C3)=CC=C3OC2=CC(F)=C(F)C=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SNAP 94847 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 51.5 | 100 | |
| ethanol | 51.5 | 100 |
制备储备液 for SNAP 94847 hydrochloride
以下数据基于产品分子量 515.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.71 mL | 19.42 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for SNAP 94847 hydrochloride
参考文献 for SNAP 94847 hydrochloride
参考文献是支持产品生物活性的出版物。
Chen et al (2007) Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key features of HTS hits. J.Med.Chem. 50 3883 PMID: 17668922
David et al (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of J.Pharmacol.Exp.Ther. 321 237 PMID: 17237257
Nair et al (2009) Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Psychopharmacology 205 129 PMID: 19340414
If you know of a relevant reference for SNAP 94847 hydrochloride, please let us know.
关键词: SNAP 94847 hydrochloride, SNAP 94847 hydrochloride supplier, Potent, selective, MCH1, antagonists, Melanin-concentrating, Hormone, Receptors, SNAP94847, hydrochloride, MCHR1, MCH1R, 487051-12-7, 3347, Tocris Bioscience
1 篇 SNAP 94847 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SNAP 94847 hydrochloride 的部分引用包括：
Kim and Han (2016) Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors. Exp Neurobiol 25 163 PMID: 27574483
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