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Submit ReviewSodium 4-Phenylbutyrate
说明： Histone deacetylase inhibitor
别名： 4-PB,Sodium phenylbutyrate
化学名： 4-Phenylbutyric acid, sodium salt
纯度： ≥99% (HPLC)
生物活性 for Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Sodium 4-Phenylbutyrate also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.
化合物库 for Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Sodium 4-Phenylbutyrate
| 分子量 | 186.18 |
| 公式 | C10H11NaO2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1716-12-7 |
| PubChem ID | 5258 |
| InChI Key | VPZRWNZGLKXFOE-UHFFFAOYSA-M |
| Smiles | [Na+].[O-]C(=O)CCCC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Sodium 4-Phenylbutyrate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.61 | 100 | |
| DMSO | 4.65 | 25 |
制备储备液 for Sodium 4-Phenylbutyrate
以下数据基于产品分子量 186.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.37 mL | 26.86 mL | 53.71 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 10 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.07 mL |
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产品说明书 for Sodium 4-Phenylbutyrate
参考文献 for Sodium 4-Phenylbutyrate
参考文献是支持产品生物活性的出版物。
Appelskog et al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419 PMID: 15138583
Ammerpohl et al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73 PMID: 17164759
Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 37 97 PMID: 9524087
Khan et al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977 PMID: 21894430
If you know of a relevant reference for Sodium 4-Phenylbutyrate, please let us know.
关键词: Sodium 4-Phenylbutyrate, Sodium 4-Phenylbutyrate supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, 4-PB, Sodium, phenylbutyrate, Non-selective, HDACs, Non-Selective, 2682, Tocris Bioscience
2 篇 Sodium 4-Phenylbutyrate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Sodium 4-Phenylbutyrate 的部分引用包括：
Myszor et al (2019) Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity. Sci Rep 9 7114 PMID: 31068616
Karadottir et al (2015) Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells. Oncotarget 3 e1483 PMID: 26664810
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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