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说明： Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
纯度： ≥95% (HPLC)
生物活性 for SP 10
SP 10 is a peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro.
Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).
技术数据 for SP 10
| 分子量 | 1315.5 |
| 公式 | C56H94N14O20S |
| 序列 | STSQKSIVAYTM |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 882157-88-2 |
| PubChem ID | 11693850 |
| InChI Key | RBLTWUZIFRZOSV-SQWMWQRLSA-N |
| Smiles | O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SP 10
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for SP 10
参考文献 for SP 10
参考文献是支持产品生物活性的出版物。
Ho et al (2006) Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 69 70 PMID: 16337697
If you know of a relevant reference for SP 10, please let us know.
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关键词: SP 10, SP 10 supplier, SP10, SARS, CoV, spike, protein, peptide, potent, inhibitors, inhibits, ACE2, interaction, 7322, Tocris Bioscience
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