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Submit ReviewSpantide I
说明： Selective NK1 antagonist
别名： [D-Arg1,D-Trp7,9,Leu11]-Substance P
生物活性 for Spantide I
Spantide I is a selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
技术数据 for Spantide I
| 分子量 | 1497.8 |
| 公式 | C75H108N20O13 |
| 序列 |
RPKPQQWFWLL (Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp) |
| 储存 | Desiccate at -20°C |
| CAS Number | 91224-37-2 |
| PubChem ID | 25079075 |
| InChI Key | SAPCBHPQLCZCDV-CHPWDEGWSA-N |
| Smiles | [H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Spantide I
参考文献 for Spantide I
参考文献是支持产品生物活性的出版物。
Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793 PMID: 7682138
Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449 PMID: 6207886
Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13 PMID: 10808247
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关键词: Spantide I, Spantide I supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, [D-Arg1,D-Trp7,9,Leu11]-Substance, P, Receptor, 1784, Tocris Bioscience
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