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SPP 86

Cat. No. 5391 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent RET inhibitor
化学名： 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SPP 86

SPP 86 is a potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.

化合物库 for SPP 86

SPP 86 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SPP 86

分子量 277.32
公式 C16H15N5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1357349-91-7
PubChem ID 66549796
InChI Key JQOIRTDBHMDWMT-UHFFFAOYSA-N
Smiles CC(C)N1N=C(C#CC3=CC=CC=C3)C2=C1N=CN=C2N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SPP 86

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.73 100
ethanol 5.55 20

制备储备液 for SPP 86

以下数据基于产品分子量 277.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.06 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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参考文献 for SPP 86

参考文献是支持产品生物活性的出版物。

Dinér et al (2012) Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 55 4872 PMID: 22559926

Klein et al (2011) Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 6 e20789 PMID: 21698101

If you know of a relevant reference for SPP 86, please let us know.

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关键词: SPP 86, SPP 86 supplier, SPP86, RET, REarranged, during, Transfection, tyrosine, kinases, potent, inhibitors, inhibits, antiproliferative, Other, RTKs, 5391, Tocris Bioscience

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