主页 / 药理学 / Nuclear Receptors / PPARs / PPARγ / PPARγ Antagonists / SR 16832

SR 16832

Cat. No. 6383 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dual site PPARγ inhibitor
化学名： 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 16832

SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).

化合物库 for SR 16832

SR 16832 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 16832

分子量 357.75
公式 C17H12ClN3O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2088135-12-8
PubChem ID 134160241
InChI Key CVTZAGCRUDYUGB-UHFFFAOYSA-N
Smiles COC1=CC2=C(N=CC=C2NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 16832

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.89 50

制备储备液 for SR 16832

以下数据基于产品分子量 357.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.59 mL 27.95 mL 55.9 mL
2.5 mM 1.12 mL 5.59 mL 11.18 mL
5 mM 0.56 mL 2.8 mL 5.59 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for SR 16832

参考文献是支持产品生物活性的出版物。

Brust et al (2017) Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 12 969 PMID: 28165718

If you know of a relevant reference for SR 16832, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PPARγ Antagonists

关键词: SR 16832, SR 16832 supplier, SR16832, PPAR, gamma, peroxisome, proliferator, activated, receptor, inhibitors, inhibits, PPARgamma, Receptors, 6383, Tocris Bioscience

2 篇 SR 16832 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 16832 的部分引用包括：

Christine et al (2020) Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nat Commun 11 2123 PMID: 32358558

Clary B et al (2021) SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Rep 36 109345 PMID: 34260923

您是否知道使用了 Tocris SR 16832 的优秀论文？ 请告知我们.

SR 16832 的评论

目前没有该产品的评论。 Be the first to review SR 16832 and earn rewards!

Have you used SR 16832?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review