SSR 146977 hydrochloride

Cat. No. 3297 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective NK₃ antagonist

化学名： N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SSR 146977 hydrochloride

SSR 146977 hydrochloride is a potent and selective NK₃ receptor antagonist (K_i values are 0.26 and 19.3 nM in CHO cells expressing the human NK₃ and NK₂ receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC₅₀ = 10 nM).

化合物库 for SSR 146977 hydrochloride

SSR 146977 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SSR 146977 hydrochloride

分子量	658.11
公式	C₃₅H₄₂Cl₂N₄O₂.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	264618-38-4
PubChem ID	90488827
InChI Key	HYPKKQPFHSNZBY-GXUZKUJRSA-N
Smiles	O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SSR 146977 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	65.81	100
	ethanol	65.81	100

制备储备液 for SSR 146977 hydrochloride

以下数据基于产品分子量 658.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.6 mL	15.2 mL
5 mM	0.3 mL	1.52 mL	3.04 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

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产品说明书 for SSR 146977 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SSR 146977 hydrochloride

参考文献是支持产品生物活性的出版物。

Emonds-Alt et al (2002) Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 80 482 PMID: 12056557

If you know of a relevant reference for SSR 146977 hydrochloride, please let us know.

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