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Submit ReviewSSR 180711 hydrochloride
说明： Selective α7 nAChR partial agonist
化学名： 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SSR 180711 hydrochloride
SSR 180711 hydrochloride is a partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
技术数据 for SSR 180711 hydrochloride
| 分子量 | 361.66 |
| 公式 | C14H17BrN2O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 446031-79-4 |
| PubChem ID | 9928899 |
| InChI Key | YNBXNVUZXFMNSJ-UHFFFAOYSA-N |
| Smiles | O=C(N1C2CCN(CC2)CC1)OC3=CC=C(Br)C=C3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SSR 180711 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 36.17 | 100 | |
| DMSO | 36.17 | 100 |
制备储备液 for SSR 180711 hydrochloride
以下数据基于产品分子量 361.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.83 mL | 27.65 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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产品说明书 for SSR 180711 hydrochloride
参考文献 for SSR 180711 hydrochloride
参考文献是支持产品生物活性的出版物。
Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673 PMID: 24057763
Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17 PMID: 16936709
If you know of a relevant reference for SSR 180711 hydrochloride, please let us know.
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关键词: SSR 180711 hydrochloride, SSR 180711 hydrochloride supplier, SSR180711, hydrochloride, partial, agonists, a7, nAChR, nicotine, acetylcholine, receptor, schizophrenia, episodic, memory, antidepressant, Nicotinic, (a7), Receptors, 5559, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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