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STING Degrader SP23

Cat. No. 8053 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective STING Degrader (PROTAC®)
化学名： (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for STING Degrader SP23

STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC®; DC50 = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI 3-K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.

Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) and STING/TMEM173 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF6516 and NBP3-18816.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for STING Degrader SP23

分子量 699.68
公式 C34H33N7O10
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2762552-74-7
PubChem ID 164886634
InChI Key TXNQXRGOKABDOB-FOCLMDBBSA-N
Smiles O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for STING Degrader SP23

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 69.97 100

制备储备液 for STING Degrader SP23

以下数据基于产品分子量 699.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.43 mL 7.15 mL 14.29 mL
5 mM 0.29 mL 1.43 mL 2.86 mL
10 mM 0.14 mL 0.71 mL 1.43 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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产品说明书 for STING Degrader SP23

分析证书/产品说明书
化学品安全技术说明书

参考文献 for STING Degrader SP23

参考文献是支持产品生物活性的出版物。

Liu et al (2022) Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 65 6593 PMID: 35452223

If you know of a relevant reference for STING Degrader SP23, please let us know.

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia