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Submit ReviewStressin I
说明： CRF1 agonist
别名： cyclo(31-34)[D-Phe12,Nle21,38,Glu31,Lys34]Ac-hCRF (4-41)
纯度： ≥95% (HPLC)
生物活性 for Stressin I
Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
许可信息
Sold with the permission of the SALK Institute
技术数据 for Stressin I
| 分子量 | 4472.24 |
| 公式 | C203H337N57O56 |
| 序列 |
PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 935739-46-1 |
| PubChem ID | 90479815 |
| InChI Key | HZKFMBAUDWRPRY-WNBAZHKDSA-N |
| Smiles | CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Stressin I
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Stressin I
参考文献 for Stressin I
参考文献是支持产品生物活性的出版物。
Rivier et al (2007) Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668 PMID: 17335188
Rivier et al (2002) Receptor-selective cortico. releasing factor analogs. Endocrin.Soc.Abstr. P2-50
Bruchas et al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528 PMID: 20052275
If you know of a relevant reference for Stressin I, please let us know.
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关键词: Stressin I, Stressin I supplier, CRF1, agonists, Corticotropin-Releasing, Factor1, Receptors, Factor, StressinI, cyclo(31-34)[D-Phe12,Nle21,38,Glu31,, Lys34]Ac-hCRF, (4-41), 1608, Tocris Bioscience
2 篇 Stressin I 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Stressin I 的部分引用包括：
Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology 70 316 PMID: 23470280
Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407 PMID: 18184783
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.