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Submit ReviewSU 3327
说明： Selective JNK inhibitor
别名： Halicin
化学名： 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
纯度： ≥99% (HPLC)
生物活性 for SU 3327
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.
化合物库 for SU 3327
SU 3327 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SU 3327
| 分子量 | 261.3 |
| 公式 | C5H3N5O2S3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 40045-50-9 |
| PubChem ID | 11837140 |
| InChI Key | NQQBNZBOOHHVQP-UHFFFAOYSA-N |
| Smiles | NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SU 3327
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.13 | 100 | |
| ethanol | 2.61 | 10 |
制备储备液 for SU 3327
以下数据基于产品分子量 261.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.14 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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产品说明书 for SU 3327
参考文献 for SU 3327
参考文献是支持产品生物活性的出版物。
De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943 PMID: 19271755
Higashihira et al (2022) Halicin is effective against staphylococcus aureus biofilms in vitro. Clin.Orthop.Relat.Res. 480 1476 PMID: 35583504
If you know of a relevant reference for SU 3327, please let us know.
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关键词: SU 3327, SU 3327 supplier, SU3327, JNK, kinases, inhibitors, inhibits, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, Halicin, antibiotic, JNK/c-jun, Antibiotics, 3607, Tocris Bioscience
4 篇 SU 3327 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SU 3327 的部分引用包括：
Jang et al (2015) Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. J Biol Chem 6 552 PMID: 26491845
van Gent et al (2022) Synergism between the synthetic antibacterial and antibiofilm peptide (SAAP)-148 and halicin. Antibiotics (Basel) 11 673 PMID: 35625317
Lo et al (2014) TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin 35 339 PMID: 24487964
Shaw and Lloyd (2012) Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Redox Biol 84 155 PMID: 22683469
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SU 3327
