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Sumatriptan succinate

Cat. No. 3586 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： 5-HT1A, 5-HT1B and 5-HT1D agonist
别名： GR 43175
化学名： 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sumatriptan succinate

Sumatriptan succinate is a 5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.

化合物库 for Sumatriptan succinate

Sumatriptan succinate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Sumatriptan succinate

分子量 413.49
公式 C14H21N3O2S.C4H6O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 103628-48-4
PubChem ID 59772
InChI Key PORMUFZNYQJOEI-UHFFFAOYSA-N
Smiles O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sumatriptan succinate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 41.35 100
DMSO 31.01 75

制备储备液 for Sumatriptan succinate

以下数据基于产品分子量 413.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for Sumatriptan succinate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Sumatriptan succinate

参考文献是支持产品生物活性的出版物。

Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133 PMID: 2545459

Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554 PMID: 2177047

Ottani et al (2004) Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 497 181 PMID: 15306203

If you know of a relevant reference for Sumatriptan succinate, please let us know.

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关键词: Sumatriptan succinate, Sumatriptan succinate supplier, 5-HT1A/1B/1D, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, GR, 43175, Non-selective, 5-HT1, 5-HT1B, 5-HT1D, 3586, Tocris Bioscience

4 篇 Sumatriptan succinate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sumatriptan succinate 的部分引用包括：

Veronica A et al (2022) Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep 39 110795 PMID: 35545050

Matsui & Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Leon F et al (2019) Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide. J Pharmacol Exp Ther 369 26-36 PMID: 30643015

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

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Sumatriptan succinate 的评论

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Inhibition of Synaptic Transmission in the VP.
By Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse

sumatriptan (1 μΜ)

PMID: 29949769
review image

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.