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Sunitinib malate

Cat. No. 3768 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent VEGFR, PDGFRβ and KIT inhibitor
别名： SU 11248
化学名： N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sunitinib malate

Sunitinib malate is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Sunitinib malate

Sunitinib malate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Sunitinib malate

分子量 532.56
公式 C22H27FN4O2.C4H6O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 341031-54-7
PubChem ID 6456015
InChI Key LBWFXVZLPYTWQI-IPOVEDGCSA-N
Smiles O=C(NCCN(CC)CC)C1=C(C)NC(/C=C2\C(NC3=C2C=C(F)C=C3)=O)=C1C.OC(C[C@H](O)C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sunitinib malate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 13.31 25

制备储备液 for Sunitinib malate

以下数据基于产品分子量 532.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 7.51 mL 37.55 mL 75.11 mL
1.25 mM 1.5 mL 7.51 mL 15.02 mL
2.5 mM 0.75 mL 3.76 mL 7.51 mL
12.5 mM 0.15 mL 0.75 mL 1.5 mL

Molarity Calculator

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产品说明书 for Sunitinib malate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Sunitinib malate

参考文献是支持产品生物活性的出版物。

Mendel et al (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin.Cancer Res. 9 327 PMID: 12538485

O'Farrell et al (2003) SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101 3597 PMID: 12531805

Faivre et al (2007) Molecular basis for suni. efficacy and future clinical development Nat.Rev.Drug Discov. 6 734 PMID: 17690708

Roskoski (2007) Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem.Biophys.Res.Comm. 356 323 PMID: 17367763

If you know of a relevant reference for Sunitinib malate, please let us know.

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关键词: Sunitinib malate, Sunitinib malate supplier, Potent, VEGFR, PDGRb, PDGFRbeta, PDGFRβ, FGFR, inhibitors, inhibits, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Flk, Kit, Receptor, Tyrosine, Kinases, RTKs, Fibroblast, platelet, derived, CD117, SU11248, Pfizer, SU, 11248, PDGFR, Other, 3768, Tocris Bioscience

4 篇 Sunitinib malate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sunitinib malate 的部分引用包括：

Procaccia et al (2014) Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun 448 134 PMID: 24759231

Goel et al (2014) VEGF???-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. ACS Appl Mater Interfaces 6 21677 PMID: 25353068

Gaji et al (2014) Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother 58 2598 PMID: 24550330

Mathew et al (2015) Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Cell Death Differ 8 ra42 PMID: 25943352

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Sunitinib malate

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.