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Submit ReviewT 0070907
说明： Highly potent and selective covalent PPARγ antagonist
化学名： 2-Chloro-5-nitro-N-4-pyridinylbenzamide
纯度： ≥99% (HPLC)
生物活性 for T 0070907
T 0070907 is a potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.
化合物库 for T 0070907
T 0070907 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for T 0070907
| 分子量 | 277.67 |
| 公式 | C12H8N3O3Cl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 313516-66-4 |
| PubChem ID | 2777391 |
| InChI Key | FRPJSHKMZHWJBE-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for T 0070907
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.8 | 100 | |
| 1eq. HCl | 27.77 | 100 |
制备储备液 for T 0070907
以下数据基于产品分子量 277.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.6 mL | 18.01 mL | 36.01 mL |
| 5 mM | 0.72 mL | 3.6 mL | 7.2 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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产品说明书 for T 0070907
参考文献 for T 0070907
参考文献是支持产品生物活性的出版物。
Lee et al (2002) T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J.Biol.Chem. 277 19649 PMID: 11877444
Rockwell and Kaminski (2004) A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J.Pharmacol.Exp.Ther. 311 683 PMID: 15284281
Schaefer et al (2005) Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 65 2251 PMID: 15781638
If you know of a relevant reference for T 0070907, please let us know.
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关键词: T 0070907, T 0070907 supplier, potent, selective, PPARγ, PPARgamma, antagonists, Peroxisome, Proliferator-activating, Receptors, T0070907, 2301, Tocris Bioscience
5 篇 T 0070907 的引用文献
引用文献是使用了 Tocris 产品的出版物。 T 0070907 的部分引用包括：
Hamtiaux et al (2011) Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One 6 e26823 PMID: 22046372
Fellous et al (2020) Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets Biochemical Pharmacology 175 PMID: 32061773
Hamtiaux et al (2012) The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer 12 92 PMID: 22429826
Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390 PMID: 24548290
Kassotis et al (2017) Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. Sci Rep 7 42104 PMID: 28176856
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T 0070907 的评论
平均评分: 5 (Based on 1 Review.)
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T 0070907 inhibits 15d-PGJ2-induced ERK activation in cardiomyocytes.
By
Chintan Koyani on 12/10/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： HL-1 cardiomyocytes
HL-1 cardiomyocytes were incubated with T 0070907 (1 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with T 0070907 completely abolished activation of p42/44 MAPK indicating involvement of PPAR gamma in cellular signalling in response to 15d-PGJ2.
