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T 26c disodium salt

Cat. No. 6134 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6134 has been discontinued.

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说明： Highly potent and selective MMP13 inhibitor
化学名： Disodium 4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for T 26c disodium salt

T 26c disodium salt is a highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T-26c probe summary on the SGC website.

技术数据 for T 26c disodium salt

分子量 523.47
公式 C24H19N3Na2O6S
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 869298-22-6
PubChem ID 131954584
InChI Key MJSVEIMIMXVRNJ-UHFFFAOYSA-L
Smiles COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for T 26c disodium salt

分析证书/产品说明书
化学品安全技术说明书

参考文献 for T 26c disodium salt

参考文献是支持产品生物活性的出版物。

Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID: 25192810

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