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Submit ReviewT16Ainh - A01
Discontinued Product
4538 has been discontinued.
View all Calcium-activated Chloride Channels products.
说明： Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
化学名： 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
纯度： ≥98% (HPLC)
生物活性 for T16Ainh - A01
T16Ainh - A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
技术数据 for T16Ainh - A01
| 分子量 | 416.52 |
| 公式 | C19H20N4O3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 552309-42-9 |
| PubChem ID | 3193184 |
| InChI Key | QSIYTNYMBWYHAA-UHFFFAOYSA-N |
| Smiles | CC1=NC(SCC(NC2=NC(C3=CC=C(OC)C=C3)=CS2)=O)=NC(O)=C1CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for T16Ainh - A01
参考文献 for T16Ainh - A01
参考文献是支持产品生物活性的出版物。
Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298
Mroz and Keely (2012) Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells. J.Physiol. 590 1907 PMID: 22351639
Duvvuri et al (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. [Epub ahead of print] PMID: 22564524
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关键词: T16Ainh - A01, T16Ainh - A01 supplier, T16Ainh-A01, supplier, ca2+, calcium, activated, sensitive, chloride, Cl-, channels, CaCC, transmembrane, TMEM16A, inhibitors, inhibits, antiproliferative, antitumor, Ca2+-Activated, Chloride, Channels, 4538, Tocris Bioscience
8 篇 T16Ainh - A01 的引用文献
引用文献是使用了 Tocris 产品的出版物。 T16Ainh - A01 的部分引用包括：
Bijos et al (2014) Anoctamin-1 in the juvenile rat urinary bladder. PLoS One 9 e106190 PMID: 25181534
Bill et al (2014) Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics. J Biol Chem 289 11029 PMID: 24599954
Jeon et al (2013) Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One 8 e67989 PMID: 23840801
Kusuda et al (2019) Long-term DEX treatment diminishes store-operated Ca2+ entry in salivary acinar cells. Int J Oral Sci 11 1 PMID: 30602784
Zhang et al (2015) TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients. Mol Pain 7 367 PMID: 25749771
Pineda-Farias et al (2015) Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Cell Death Dis 11 41 PMID: 26130088
Zhang et al (2015) Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS One 10 e0142160 PMID: 26558388
Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. PLoS One 4 e969 PMID: 24357800
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for T16Ainh - A01
