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说明： Induces cardiomyocyte differentiation from hESCs
化学名： 4-(2-(2,6-Difluorophenyl)-4-(fluorophenyl)-1H-imidazol-5-yl)pyridine
纯度： ≥98% (HPLC)
生物活性 for TA 01
Induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively).
许可信息
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Bioprocessing Technology Institute.
技术数据 for TA 01
| 分子量 | 351.32 |
| 公式 | C20H12F3N3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 91691129 |
| InChI Key | TWPJJJZCYVFUOA-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4C(N=C(C3=C(F)C=CC=C3F)N2)=C2C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TA 01
参考文献 for TA 01
参考文献是支持产品生物活性的出版物。
Laco et al (2014) Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J.Mol.Cell.Cardiol 80 56 PMID: 25528965
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关键词: TA 01, TA 01 supplier, TA01, induces, cardiomyocyte, differentiation, human, pluripotent, stem, cells, hpsc, inhibits, inhibitors, ck1eta, ck1e, ck1δ, ck1delta, ck1d, ck1ε, p38alpha, p38a, p38α, mapk, casein, kinase, p38, Casein, Kinase, 1, ESCs, and, iPSC, Cardiomyocyte, Stem, Cells, 5383, Tocris Bioscience
1 篇 TA 01 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TA 01 的部分引用包括：
Laco et al (2018) Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells. Stem Cell Reports 10 1851 PMID: 29706502
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.