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Submit ReviewTAK 375
说明： Very high affinity and selective melatonin receptor agonist
别名： Ramelteon
化学名： N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
纯度： ≥98% (HPLC)
生物活性 for TAK 375
TAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.
化合物库 for TAK 375
TAK 375 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for TAK 375
| 分子量 | 259.34 |
| 公式 | C16H21NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 196597-26-9 |
| PubChem ID | 208902 |
| InChI Key | YLXDSYKOBKBWJQ-LBPRGKRZSA-N |
| Smiles | CCC(NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TAK 375
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.93 | 100 | |
| ethanol | 25.93 | 100 |
制备储备液 for TAK 375
以下数据基于产品分子量 259.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.86 mL | 19.28 mL | 38.56 mL |
| 5 mM | 0.77 mL | 3.86 mL | 7.71 mL |
| 10 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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产品说明书 for TAK 375
参考文献 for TAK 375
参考文献是支持产品生物活性的出版物。
Stroethoff et al (2018) Melatonin receptor agonist rame. reduces ischemia-reperfusion injury through activation of mitochondrial potassium channels. J.Cardiovasc.Pharmacol. 72 106 PMID: 29787401
Hirai et al (2005) Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats J.Biol.Rhythms. 20 27 PMID: 15654068
Kato et al (2005) Neurochemical properties of rame. (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 48 301 PMID: 15695169
If you know of a relevant reference for TAK 375, please let us know.
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关键词: TAK 375, TAK 375 supplier, TAK375, melatonin, receptor, agonists, agonism, selective, very, high, affinity, MT1, MT2, circadian, rhythm, Ramelteon, Melatonin, (MT), Receptors, 6777, Tocris Bioscience
1 篇 TAK 375 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TAK 375 的部分引用包括：
Jae-Sung et al (2019) Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end-joining repair. J Pineal Res 67 e12603 PMID: 31370106
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TAK 375 的评论
平均评分: 4 (Based on 1 Review.)
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Activates the MT receptors.
By
Anonymous on 04/07/2022
分析类型： In Vitro
种属： Human
细胞系/组织： Cancer and primary liver cell lines
I used TAK 375 for cell growth analysis and western blotting analysis
