TAK 715

Cat. No. 4254 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent p38 MAPK inhibitor; anti-inflammatory

化学名： N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide

纯度： ≥99% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAK 715

TAK 715 is an inhibitor of p38 MAPK (IC₅₀ = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

化合物库 for TAK 715

TAK 715 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TAK 715

分子量	399.51
公式	C₂₄H₂₁N₃OS
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	303162-79-0
PubChem ID	90488922
InChI Key	BRYAJHADJWBFQY-UHFFFAOYSA-N
Smiles	CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAK 715

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.95	100
	ethanol	19.98	50

制备储备液 for TAK 715

以下数据基于产品分子量 399.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.5 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for TAK 715

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAK 715

参考文献是支持产品生物活性的出版物。

Miwatashi et al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966 PMID: 16162000

Verkaar et al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485 PMID: 21513885

If you know of a relevant reference for TAK 715, please let us know.

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关键词: TAK 715, TAK 715 supplier, TAK715, p38, MAPK, inhibitors, Mitogen-activated, protein, kinase, anti-inflammatory, inhibits, wnt, b-catenin, inhibitor, beta-catenin, casein, Casein, Kinase, 1, Beta-catenin, 4254, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TAK 715

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.