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Tanshinone IIA

Cat. No. 4426 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4426 has been discontinued.

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说明： Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
化学名： 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Tanshinone IIA

Tanshinone IIA is a major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.

技术数据 for Tanshinone IIA

分子量 294.34
公式 C19H18O3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 568-72-9
PubChem ID 164676
InChI Key HYXITZLLTYIPOF-UHFFFAOYSA-N
Smiles O=C(C1=C(C4=C3C(C)=CO4)C=CC2=C1CCCC(C)2C)C3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Tanshinone IIA

参考文献是支持产品生物活性的出版物。

Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527 PMID: 19001436

Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11 PMID: 16955220

Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15 PMID: 17979138

Dong et al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495 PMID: 22314911

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关键词: Tanshinone IIA, Tanshinone IIA supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding, amyloidbeta, amyloidb, amyloidβ, Antioxidants, NF-kB/IkB, Amyloid, Beta, Peptides, 4426, Tocris Bioscience

1 篇 Tanshinone IIA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tanshinone IIA 的部分引用包括：

Pedersen et al (2012) RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1. J Cell Sci 125 5379 PMID: 22956547

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Pathways for Tanshinone IIA

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.