TAPI 1

Pricing Availability   Qty
说明: ADAM-17 (TACE) and MMP inhibitor
化学名: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
纯度: ≥95% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for TAPI 1

TAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.

This product is typically reconstituted in DMSO.

技术数据 for TAPI 1

分子量 499.6
公式 C26H37N5O5
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 163847-77-6
PubChem ID 9827273
InChI Key AWNBSWDIOCXWJW-OWHMDLSXSA-N
Smiles ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TAPI 1

分析证书/产品说明书
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参考文献 for TAPI 1

参考文献是支持产品生物活性的出版物。

Sommer et al (1997) A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci. Lett. 237 45 PMID: 9406876

Mohler et al (1994) Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370 218 PMID: 8028669


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关键词: TAPI 1, TAPI 1 supplier, TAPI1, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, ADAMs, Matrix, Metalloprotease, 6162, Tocris Bioscience

1 篇 TAPI 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TAPI 1 的部分引用包括:

Franck et al (2020) Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling. Dev Cell 52 104-117.e5 PMID: 31866204


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