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说明： ADAM-17 (TACE) and MMP inhibitor
化学名： N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
纯度： ≥95% (HPLC)
生物活性 for TAPI 2
TAPI 2 is an ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.
This product is typically reconstituted in water.
技术数据 for TAPI 2
| 分子量 | 415.54 |
| 公式 | C19H37N5O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 689284-12-6 |
| PubChem ID | 10093303 |
| InChI Key | LMIQCBIEAHJAMZ-RMTCENKZSA-N |
| Smiles | ONC(C[C@@H](CC(C)C)C(N[C@@H](C(C)(C)C)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TAPI 2
参考文献 for TAPI 2
参考文献是支持产品生物活性的出版物。
Moss et al (2007) Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal.Biochem. 366 144 PMID: 17548045
Wang et al (2016) A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via notch1 signaling. Stem Cells Transl.Med. 5 331 PMID: 26744411
If you know of a relevant reference for TAPI 2, please let us know.
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关键词: TAPI 2, TAPI 2 supplier, TAPI2, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, ADAMs, Matrix, Metalloprotease, 6013, Tocris Bioscience
2 篇 TAPI 2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TAPI 2 的部分引用包括：
Hui et al (2014) A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell 25 3798-812 PMID: 25232008
Jian et al (2020) Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. Cancer Immunol Res 8 1554-1567 PMID: 33051240
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