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TASP 0277308

Cat. No. 6498 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
化学名： 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TASP 0277308

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

技术数据 for TASP 0277308

分子量 539.48
公式 C23H28Cl2N6O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 945725-50-8
PubChem ID 56935569
InChI Key MVOULGOLHZCXLD-MRXNPFEDSA-N
Smiles CCN1C(OC2=CC(N3CCN(CC3)C)=CC=C2)=NN=C1[C@H](NS(=O)(C4=CC(Cl)=C(C=C4)Cl)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TASP 0277308

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.7 5

制备储备液 for TASP 0277308

以下数据基于产品分子量 539.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 37.07 mL 185.36 mL 370.73 mL
0.25 mM 7.41 mL 37.07 mL 74.15 mL
0.5 mM 3.71 mL 18.54 mL 37.07 mL
2.5 mM 0.74 mL 3.71 mL 7.41 mL

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参考文献 for TASP 0277308

参考文献是支持产品生物活性的出版物。

Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329

Fujii et al (2012) Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 419 754 PMID: 22387544

If you know of a relevant reference for TASP 0277308, please let us know.

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关键词: TASP 0277308, TASP 0277308 supplier, TASP0277308, potent, selective, sphingosine, 1-phosphate, antagonists, S1P1-receptors, Sphingosine-1-phosphate, Receptors, Antiangiogenics, 6498, Tocris Bioscience

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