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Submit ReviewTASP 0390325
说明： Potent and selective V1B receptor antagonist; orally bioavailable
化学名： 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for TASP 0390325
TASP 0390325 is a potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.
化合物库 for TASP 0390325
TASP 0390325 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for TASP 0390325
| 分子量 | 554.44 |
| 公式 | C25H29ClFN5O4.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1642187-96-9 |
| PubChem ID | 86765292 |
| InChI Key | NUIXGNLBPARAII-UHFFFAOYSA-N |
| Smiles | O=C(NC(C)C)CN1C(C2=CC(OCCCN3CCOCC3)=CN=C2N=C1C4=CC=C(F)C(Cl)=C4)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TASP 0390325
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 55.44 | 100 | |
| DMSO | 55.44 | 100 |
制备储备液 for TASP 0390325
以下数据基于产品分子量 554.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 9.02 mL | 18.04 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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产品说明书 for TASP 0390325
参考文献 for TASP 0390325
参考文献是支持产品生物活性的出版物。
Iijima et al (2014) Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 171 3511 PMID: 24654684
If you know of a relevant reference for TASP 0390325, please let us know.
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关键词: TASP 0390325, TASP 0390325 supplier, TASP0390325, vasopressin, receptors, antagonists, antagonism, potent, selective, V1B, anxiolytic, anxiety, antidepressant, depression, Vasopressin, Receptors, 5729, Tocris Bioscience
1 篇 TASP 0390325 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TASP 0390325 的部分引用包括：
Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.