TAT-cyclo-CLLFVY

Cat. No. 5582 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective HIF-1 dimerization inhibitor

纯度： ≥95% (HPLC)

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC₅₀ = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

技术数据 for TAT-cyclo-CLLFVY

分子量	2559.1
公式	C₁₁₁H₁₈₈N₄₂O₂₄S₂
序列	CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1446322-66-2
PubChem ID	72192490
InChI Key	AWUUHEHYNQGEFC-XLZVTALKSA-N
Smiles	[H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for TAT-cyclo-CLLFVY

溶解性	Soluble to 1 mg/ml in water

产品说明书 for TAT-cyclo-CLLFVY

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAT-cyclo-CLLFVY

参考文献是支持产品生物活性的出版物。

Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID: 23796364

If you know of a relevant reference for TAT-cyclo-CLLFVY, please let us know.

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关键词: TAT-cyclo-CLLFVY, TAT-cyclo-CLLFVY supplier, HIF-1a, 1b, 1beta, 1alpha, α, β, hypoxia, inducible, factor, cancer, angiogenesis, antiangiogenic, dimerization, inhibitors, inhibits, Hypoxia, Inducible, Factors, 5582, Tocris Bioscience

1 篇 TAT-cyclo-CLLFVY 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TAT-cyclo-CLLFVY 的部分引用包括：

Ying et al (2022) CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy 18 726-744 PMID: 34282994

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