TC AC 28

Discontinued Product

6105 has been discontinued.

View all Bromodomains products.
说明: High affinity BET bromodomain ligand
化学名: 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
纯度: ≥98% (HPLC)
说明书
引用文献
评论
文献 (4)

生物活性 for TC AC 28

TC AC 28 is a high affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.

许可信息

Sold under licence from the University of Dundee.

技术数据 for TC AC 28

分子量 415.44
公式 C23H21N5O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1809296-92-1
PubChem ID 118121364
InChI Key RARZHTSXOQRRPR-UHFFFAOYNA-N
Smiles COC(CC1N=C(C2=CC(OC)=CC=C2N3C(C)=NN=C13)C4=C5C=CNC5=CC=C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC AC 28

参考文献是支持产品生物活性的出版物。

Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID: 26367539

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关键词: TC AC 28, TC AC 28 supplier, TCAC28, BET, bromodomain, high, affinity, binding, agents, Bromodomains, 6105, Tocris Bioscience

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