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说明： High affinity BET bromodomain ligand
化学名： 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
纯度： ≥98% (HPLC)
生物活性 for TC AC 28
TC AC 28 is a high affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.
许可信息
Sold under licence from the University of Dundee.
技术数据 for TC AC 28
| 分子量 | 415.44 |
| 公式 | C23H21N5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1809296-92-1 |
| PubChem ID | 118121364 |
| InChI Key | RARZHTSXOQRRPR-UHFFFAOYNA-N |
| Smiles | COC(CC1N=C(C2=CC(OC)=CC=C2N3C(C)=NN=C13)C4=C5C=CNC5=CC=C4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC AC 28
参考文献 for TC AC 28
参考文献是支持产品生物活性的出版物。
Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID: 26367539
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关键词: TC AC 28, TC AC 28 supplier, TCAC28, BET, bromodomain, high, affinity, binding, agents, Bromodomains, 6105, Tocris Bioscience
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