主页 / 药理学 / Enzymes / Proteases / γ-Secretase / γ-Secretase Modulators / TC-E 5006

TC-E 5006

Cat. No. 4898 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4898 has been discontinued.

说明： γ-secretase modulator; reduces Aβ42 levels
化学名： 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for TC-E 5006

TC-E 5006 is a γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

技术数据 for TC-E 5006

分子量 499.54
公式 C29H29F4NO2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1257395-14-4
PubChem ID 68414868
InChI Key ONYWALXTZFPKAS-UHFFFAOYSA-N
Smiles CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TC-E 5006

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TC-E 5006

参考文献是支持产品生物活性的出版物。

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267

按标靶查看相关产品

按产品操作查看相关产品

查看全部 γ-Secretase Modulators

关键词: TC-E 5006, TC-E 5006 supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Gamma-Secretase, 4898, Tocris Bioscience

篇 TC-E 5006 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TC-E 5006 的引用文献。

TC-E 5006 的评论

目前没有该产品的评论。 Be the first to review TC-E 5006 and earn rewards!

Have you used TC-E 5006?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.