TC-F 2

Cat. No. 4355 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, reversible and selective FAAH inhibitor

化学名： 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

纯度： ≥99% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC-F 2

TC-F 2 is a potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC₅₀ > 20 μM for CB₁, CB₂ and TRPV1). Active in vivo.

化合物库 for TC-F 2

TC-F 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-F 2

分子量	439.51
公式	C₂₆H₂₅N₅O₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1304778-15-1
PubChem ID	25198728
InChI Key	NXTBLPPTZRPJCA-IBGZPJMESA-N
Smiles	O=C(N(CC)C6=C5C=CC=C6)N5[C@H]1CCCN(C2=NC(C3=CC(C=CC=C4)=C4O3)=CC=N2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-F 2

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	43.95	100

制备储备液 for TC-F 2

以下数据基于产品分子量 439.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.38 mL	22.75 mL
5 mM	0.46 mL	2.28 mL	4.55 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for TC-F 2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-F 2

参考文献是支持产品生物活性的出版物。

Min et al (2011) Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 108 7379 PMID: 21502526

Gustin et al (2011) Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 21 2492 PMID: 21392988

If you know of a relevant reference for TC-F 2, please let us know.

按标靶查看相关产品

关键词: TC-F 2, TC-F 2 supplier, TCF2, TC-F2, fatty, acid, amide, hydrolase, FAAH, inhibits, inhibitors, reversible, noncovalent, potent, in, vivo, selective, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4355, Tocris Bioscience

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