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TC-FPR 43

Cat. No. 4624 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent FPR2 agonist
化学名： N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-FPR 43

TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

化合物库 for TC-FPR 43

TC-FPR 43 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-FPR 43

分子量 384.86
公式 C20H21ClN4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 903895-98-7
PubChem ID 24776341
InChI Key PAEBEUZTAPIOIO-UHFFFAOYSA-N
Smiles CC(C)C1=C(NC(NC3=CC=C(Cl)C=C3)=O)C(N(C2=CC=CC=C2)N1C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-FPR 43

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.49 100

制备储备液 for TC-FPR 43

以下数据基于产品分子量 384.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.99 mL 25.98 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for TC-FPR 43

参考文献是支持产品生物活性的出版物。

Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611 PMID: 20107188

Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713 PMID: 16697190

Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402 PMID: 21095183

If you know of a relevant reference for TC-FPR 43, please let us know.

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关键词: TC-FPR 43, TC-FPR 43 supplier, TC-FPR43, potent, FPR2, anti-inflammatory, GPR32, agonists, neutrophils, migration, inflammation, Formyl, Peptide, Receptors, 4624, Tocris Bioscience

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