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TC-G 1005

Cat. No. 5129 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective GPBA receptor (TGR5) agonist
化学名： (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-G 1005

TC-G 1005 is a potent and selective GPBA agonist (EC50 values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.

化合物库 for TC-G 1005

TC-G 1005 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-G 1005

分子量 399.48
公式 C25H25N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1415407-60-1
PubChem ID 71450251
InChI Key JQULIQJSYPZQMA-UHFFFAOYSA-N
Smiles CC1=CC(OC2=CC=NC=C2C(N3C(C=CC=C4)=C4N(C5CC5)CC3)=O)=C(C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-G 1005

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.95 100
ethanol 39.95 100

制备储备液 for TC-G 1005

以下数据基于产品分子量 399.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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产品说明书 for TC-G 1005

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TC-G 1005

参考文献是支持产品生物活性的出版物。

Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID: 23148522

Urso et al (2020) Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. Am.J.Physiol.Lung Cell.Mol.Physiol. 318 L264 PMID: 31800261

If you know of a relevant reference for TC-G 1005, please let us know.

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关键词: TC-G 1005, TC-G 1005 supplier, TC-G1005, TGR5, agonists, agonism, GLP-1, GPBA, glucose, bile, acid, receptors, bioavailable, TCG1005, Receptors, 5129, Tocris Bioscience

1 篇 TC-G 1005 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-G 1005 的部分引用包括：

Urso et al (2020) Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. Am.J.Physiol.Lung Cell.Mol.Physiol. 318 L264 PMID: 31800261

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Pathways for TC-G 1005

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.