主页 / 药理学 / Ion Channels / Sodium Channels / Voltage-gated Sodium (NaV) Channels / Voltage-gated Sodium (NaV) Channel Blockers / TC-N 1752

TC-N 1752

Cat. No. 4435 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： NaV channel blocker
化学名： N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-N 1752

TC-N 1752 is a human NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

化合物库 for TC-N 1752

TC-N 1752 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-N 1752

分子量 516.52
公式 C25H27F3N6O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1211866-85-1
PubChem ID 53361524
InChI Key QLKAFHZJICDACE-UHFFFAOYSA-N
Smiles CC(C(NC(C)=O)=CC=C4)=C4NC1=NC=NC(N2CCC(OCC3=CC=C(OC(F)(F)F)C=C3)CC2)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-N 1752

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.65 100
1eq. HCl 5.17 10

制备储备液 for TC-N 1752

以下数据基于产品分子量 516.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.36 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for TC-N 1752

参考文献是支持产品生物活性的出版物。

Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427 PMID: 21634377

Lin et al (2016) Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells. PLoS One. 11 PMID: 27556810

If you know of a relevant reference for TC-N 1752, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Voltage-gated Sodium (NaV) Channel Blockers

关键词: TC-N 1752, TC-N 1752 supplier, TCN1752, sodium, channels, blockers, selective, nav, analgesics, Voltage-gated, Sodium, Channels, 4435, Tocris Bioscience

2 篇 TC-N 1752 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-N 1752 的部分引用包括：

Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052

Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766 PMID: 25587718

您是否知道使用了 Tocris TC-N 1752 的优秀论文？ 请告知我们.

TC-N 1752 的评论

目前没有该产品的评论。 Be the first to review TC-N 1752 and earn rewards!

Have you used TC-N 1752?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review