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TC OT 39

Cat. No. 4625 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
化学名： (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC OT 39

TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.

化合物库 for TC OT 39

TC OT 39 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC OT 39

分子量 600.78
公式 C32H40N8O2S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 479232-57-0
PubChem ID 135413563
InChI Key KSNHHKZYKYNBEI-NDEPHWFRSA-N
Smiles O=C(N5[C@H]([C@](N6CCN(C)CCC6)=S)CCC5)NCC(C(C)=C2)=CC=C2C(N1C(C=CC=C3)=C3NC(N(C)N=C4)=C4C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC OT 39

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 100
DMSO 100

制备储备液 for TC OT 39

以下数据基于产品分子量 600.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.32 mL 16.65 mL
5 mM 0.33 mL 1.66 mL 3.33 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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参考文献 for TC OT 39

参考文献是支持产品生物活性的出版物。

Frantz et al (2010) Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist. J.Med.Chem. 53 1546 PMID: 20104850

Pitt et al (2004) Non-peptide oxyt. agonists. Bioorg.Med.Chem.Lett. 14 4585 PMID: 15357997

If you know of a relevant reference for TC OT 39, please let us know.

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关键词: TC OT 39, TC OT 39 supplier, TCOT39, nonpeptide, oxytocin, receptors, partial, agonists, vasopressin, potent, V1A, V2, Oxytocin, Receptors, Vasopressin, 4625, Tocris Bioscience

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