TC-SP 14

Name: TC-SP 14
Brand: Tocris Bioscience
SKU: 4363

Cat. No. 4363 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4363 has been discontinued.

View all Sphingosine-1-Phosphate Receptors products.

说明： Potent S1P₁ receptor agonist

化学名： 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for TC-SP 14

TC-SP 14 is a potent and selective S1P₁ agonist (EC₅₀ values are 0.042 and 3.47 μM for human S1P₁ and S1P₃ respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

技术数据 for TC-SP 14

分子量	450.5
公式	C₂₅H₂₀F₂N₂O₂S
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1257093-40-5
PubChem ID	51346934
InChI Key	GVXGVDIXINMAAL-UHFFFAOYSA-N
Smiles	FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TC-SP 14

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-SP 14

参考文献是支持产品生物活性的出版物。

Lanman et al (2011) Discovery of a potent, S1P₃-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P₁). ACS Med.Chem.Lett. 2 102

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Sphingosine-1-Phosphate Receptors

关键词: TC-SP 14, TC-SP 14 supplier, TCSP14, Potent, sphingosine, 1, phosphate, receptor, S1P1, agonist, delayed, type, hypersensitivity, immune, response, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 4363, Tocris Bioscience

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