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说明： Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
化学名： 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
纯度： ≥99% (HPLC)
生物活性 for TCID
TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
技术数据 for TCID
| 分子量 | 283.92 |
| 公式 | C9H2Cl4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 30675-13-9 |
| PubChem ID | 2729042 |
| InChI Key | IDLAOWFFKWRNHB-UHFFFAOYSA-N |
| Smiles | O=C(CC2=O)C1=C2C(Cl)=C(Cl)C(Cl)=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCID
参考文献 for TCID
参考文献是支持产品生物活性的出版物。
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054
de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054
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关键词: TCID, TCID supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Deubiquitinating, Enzymes, 5179, Tocris Bioscience
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