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TCS ERK 11e

Cat. No. 4465 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective ERK2 inhibitor
别名： VX 11e
化学名： 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TCS ERK 11e

TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

化合物库 for TCS ERK 11e

TCS ERK 11e is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS ERK 11e

分子量 500.35
公式 C24H20Cl2FN5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 896720-20-0
PubChem ID 11634725
InChI Key WUTVMXLIGHTZJC-OAQYLSRUSA-N
Smiles O=C(N[C@H](CO)C3=CC(Cl)=CC=C3)C1=CC(C2=NC(NC4=CC=C(F)C=C4Cl)=NC=C2C)=CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS ERK 11e

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.03 100
ethanol 12.51 25

制备储备液 for TCS ERK 11e

以下数据基于产品分子量 500.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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产品说明书 for TCS ERK 11e

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TCS ERK 11e

参考文献是支持产品生物活性的出版物。

Aronov et al (2009) Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control. J.Med.Chem. 52 6362 PMID: 19827834

If you know of a relevant reference for TCS ERK 11e, please let us know.

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关键词: TCS ERK 11e, TCS ERK 11e supplier, TCSERK11e, extracellular, signal, related, kinase, 2, ERK2, inhibitors, inhibits, potent, selective, cell, permeable, orally, bioavailable, VTX11e, VX11e, VX, 11e, ERK, 4465, Tocris Bioscience

2 篇 TCS ERK 11e 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TCS ERK 11e 的部分引用包括：

Rozbeh et al (2014) The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc 9 2100-22 PMID: 25101824

Kai et al (2022) Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses. Int J Mol Sci 23 PMID: 35628420

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TCS ERK 11e

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.