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Telmisartan

Cat. No. 5139 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5139 has been discontinued.

View all Angiotensin AT<sub>1</sub> Receptors products.
说明： AT1 antagonist; PPARγ partial agonist
化学名： 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Telmisartan

Telmisartan is an antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

化合物库 for Telmisartan

Telmisartan is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Telmisartan

分子量 514.62
公式 C33H30N4O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 144701-48-4
PubChem ID 65999
InChI Key RMMXLENWKUUMAY-UHFFFAOYSA-N
Smiles CCCC4=NC(C(C)=C3)=C(N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5)C=C3C2=NC1=CC=CC=C1N2C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Telmisartan

参考文献是支持产品生物活性的出版物。

Rong et al (2009) An adipose tissue-independent Ins-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096 PMID: 19770292

Benson et al (2004) Identification of telmis. as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993 PMID: 15007034

Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040 PMID: 8258826

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关键词: Telmisartan, Telmisartan supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Angiotensin, Receptors, 5139, Tocris Bioscience

2 篇 Telmisartan 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Telmisartan 的部分引用包括：

Lin et al (2015) Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709 PMID: 26316709

Josef M et al (2018) Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci 75 3625-3634 PMID: 29679094

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