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Terazosin hydrochloride

Cat. No. 1506 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： α1 antagonist; PGK1 activator
化学名： 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Terazosin hydrochloride

Terazosin hydrochloride is a selective α1 antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (Kd = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.

技术数据 for Terazosin hydrochloride

分子量 423.9
公式 C19H25N5O4.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 63074-08-8
PubChem ID 44383
InChI Key IWSWDOUXSCRCKW-UHFFFAOYSA-N
Smiles Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Terazosin hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 8.48 20 温和加热

制备储备液 for Terazosin hydrochloride

以下数据基于产品分子量 423.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.8 mL 58.98 mL 117.95 mL
1 mM 2.36 mL 11.8 mL 23.59 mL
2 mM 1.18 mL 5.9 mL 11.8 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

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产品说明书 for Terazosin hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Terazosin hydrochloride

参考文献是支持产品生物活性的出版物。

Kyncl (1986) Pharmacology of tera. Am.J.Med. 80 12 PMID: 2872801

Hancock et al (1995) Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863 PMID: 8673721

Maruyama et al (1994) Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126 PMID: 7820122

If you know of a relevant reference for Terazosin hydrochloride, please let us know.

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关键词: Terazosin hydrochloride, Terazosin hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, antagonists, Orally, active, Receptors, ALS, Parkinsons, ATP, production, PGK1, phosphoglycerate, kinase, 1antiinflammatory, neuroprotective, antihypertensive, Adrenergic, Alpha-1, Other, Kinases, 1506, Tocris Bioscience

2 篇 Terazosin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Terazosin hydrochloride 的部分引用包括：

Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

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Terazosin hydrochloride 的评论

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Used to investigate cell metabolism.
By Anonymous on 12/22/2022
分析类型： In Vitro
种属： Rat
细胞系/组织： Primary hippocampal neurons

The drug was incubated at 10 μM to investigate an effect on cell metabolism.

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