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说明： Cereblon ligand with alkyl linker and terminal acid for onward chemistry
化学名： 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic acid
纯度： ≥95% (HPLC)
生物活性 for Thalidomide 4'-ether-alkylC5-acid
Thalidomide 4'-ether-alkylC5-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with a terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for Thalidomide 4'-ether-alkylC5-acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for Thalidomide 4'-ether-alkylC5-acid
| 分子量 | 388.38 |
| 公式 | C19H20N2O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2087490-48-8 |
| PubChem ID | 132212109 |
| InChI Key | PBZGPWVWKSADLD-UHFFFAOYSA-N |
| Smiles | OC(CCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Thalidomide 4'-ether-alkylC5-acid
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关键词: Thalidomide 4'-ether-alkylC5-acid, Thalidomide 4'-ether-alkylC5-acid supplier, functionalized, PROTACs, cereblon, E3, ubiquitin, ligase, alkyl, C5, linker, conjugate, targeted, protein, degradation, TPD, building, blocks, components, Cereblon, Ligands, Plus, Linkers, 7332, Tocris Bioscience
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia