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Submit ReviewThalidomide 4'-ether-alkylC6-azide is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC3 linker with a terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
This product is provided for use in onward chemistry. Suitable solvents can be used.
分子量 | 399.41 |
公式 | C19H21N5O5 |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 2411389-65-4 |
PubChem ID | 155292156 |
InChI Key | LAINMOUUNLUPGJ-UHFFFAOYSA-N |
Smiles | O=C(N1)C(N2C(C3=C(C(OCCCCCCN=[N+]=[N-])=CC=C3)C2=O)=O)CCC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
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This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia