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Thalidomide 4'-ether-PEG1-azide

Cat. No. 7518 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cereblon ligand with PEG linker and terminal azide for onward chemistry
化学名： 4-(2-(2-Azidoethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Thalidomide 4'-ether-PEG1-azide

Thalidomide 4'-ether-PEG1-azide is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG1 linker with azide terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Thalidomide 4'-ether-PEG1-azide

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Thalidomide 4'-ether-PEG1-azide

分子量 387.35
公式 C17H17N5O6
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2758432-02-7
PubChem ID 155292157
InChI Key WCVIWNRCCKNKEA-UHFFFAOYSA-N
Smiles [N-]=[N+]=NCCOCCOC1=CC=CC(C(N2C(C(N3)=O)CCC3=O)=O)=C1C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Thalidomide 4'-ether-PEG1-azide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Thalidomide 4'-ether-PEG1-azide

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关键词: Thalidomide 4'-ether-PEG1-azide, Thalidomide 4'-ether-PEG1-azide supplier, Thalidomide4etherPEG1azide, cereblon, E3, ligase, PROTAC, protein, degraders, building, blocks, PEG1, azide, Cereblon, Ligands, Plus, Linkers, 7518, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia