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Thalidomide 4'-oxyacetamide-PEG2-amine

Cat. No. 6967 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cereblon ligand with PEG linker and terminal amine for onward chemistry
别名： Thalidomide - linker 14
化学名： N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性

Thalidomide 4'-oxyacetamide-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker with ethylamine terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 14

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据

分子量 498.92
公式 C21H26N4O8.HCl
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2376990-30-4
Smiles NCCOCCOCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.95 50
DMF 24.95 50

制备储备液

以下数据基于产品分子量 498.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.01 mL 20.04 mL 40.09 mL
2.5 mM 0.8 mL 4.01 mL 8.02 mL
5 mM 0.4 mL 2 mL 4.01 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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产品说明书

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参考文献

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关键词: Thalidomide 4'-oxyacetamide-PEG2-amine, Thalidomide 4'-oxyacetamide-PEG2-amine supplier, functionalized, thalidomide, E3, ligase, ligands, cereblon, PEG, linker, conjugate, PROTAC, targeted, protein, degradation, TPD, targeting, 1957235-74-3, Thalidomide, -, 14, Cereblon, Ligands, Plus, Linkers, 6967, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia