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Thiolutin

Cat. No. 1567 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1567 has been discontinued.

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说明： Bacterial RNA polymerase inhibitor
化学名： N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Thiolutin

Thiolutin is an antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

技术数据 for Thiolutin

分子量 228.28
公式 C8H8N2O2S2
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 87-11-6
PubChem ID 6870
InChI Key MHMRAFONCSQAIA-UHFFFAOYSA-N
Smiles O=C(N2C)C(NC(C)=O)=C1C2=CSS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Thiolutin

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参考文献 for Thiolutin

参考文献是支持产品生物活性的出版物。

Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729 PMID: 4597739

Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307 PMID: 11433393

O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163 PMID: 11036042

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关键词: Thiolutin, Thiolutin supplier, Bacterial, RNA, polymerases, inhibitors, inhibits, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam, Cell, Polymerase, 1567, Tocris Bioscience

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Study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.
By Anonymous on 02/13/2019
种属： Human

Used in study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.

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