Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTL 13-27
说明： Negative control for TL 12-186 (Cat. No. 6524)
化学名： N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
纯度： ≥98% (HPLC)
生物活性 for TL 13-27
TL 13-27 is a negative control for TL 12-186 (Cat. No. 6524). Demonstrates no kinase degradation in vitro.
技术数据 for TL 13-27
| 分子量 | 917.48 |
| 公式 | C44H53ClN10O8S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2250025-90-0 |
| PubChem ID | 134812844 |
| InChI Key | DOOUFCVVMSZNOA-UHFFFAOYSA-N |
| Smiles | O=C1C(CCCN1)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TL 13-27
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 91.75 | 100 |
制备储备液 for TL 13-27
以下数据基于产品分子量 917.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.09 mL | 5.45 mL | 10.9 mL |
| 5 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.09 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for TL 13-27
参考文献 for TL 13-27
参考文献是支持产品生物活性的出版物。
Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717
If you know of a relevant reference for TL 13-27, please let us know.
关键词: TL 13-27, TL 13-27 supplier, TL13-27, PROTAC, PROTACs, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, inhibitors, degraders, negative, controls, Other, Kinases, Negative, Controls, 6525, Tocris Bioscience
篇 TL 13-27 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 TL 13-27 的引用文献。 您是否知道使用了 Tocris TL 13-27 的优秀论文？ 请告知我们.
TL 13-27 的评论
目前没有该产品的评论。 Be the first to review TL 13-27 and earn rewards!
Have you used TL 13-27?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia